SS-31 50mg Research Peptide (Szeto–Schiller-31)

SS-31 50mg, also known as Szeto–Schiller-31 or MTP-131, is a synthetic mitochondria-targeting tetrapeptide developed for laboratory research into mitochondrial dysfunction, oxidative stress, and cellular energy regulation. SS-31 50mg is supplied as a lyophilized powder with a reported purity greater than 99% and is intended exclusively for laboratory research use.

What Is SS-31 50mg?

SS-31 50mg is a short, cell-permeable peptide designed to selectively localize to the inner mitochondrial membrane. Unlike many compounds that act indirectly on mitochondrial pathways, SS-31 has been studied for its direct interaction with cardiolipin, a phospholipid critical for maintaining mitochondrial structure and electron transport chain function.

SS-31 50mg is an experimental research compound and is not approved for human or animal use.

Research Background

SS-31 was developed to address mitochondrial instability and oxidative stress observed in numerous experimental disease and aging models. Research has shown that SS-31 accumulates within mitochondria at concentrations significantly exceeding plasma levels, suggesting selective mitochondrial targeting.

By binding cardiolipin, SS-31 has been investigated for its potential role in preserving mitochondrial cristae structure, supporting electron transport efficiency, and reducing oxidative damage associated with mitochondrial dysfunction. All findings remain preclinical and limited to laboratory and animal research.

Mechanisms of Research Interest

Cardiolipin Binding

SS-31 50mg has been studied for its ability to bind cardiolipin within the inner mitochondrial membrane. This interaction is proposed to protect cardiolipin from oxidative degradation and maintain mitochondrial membrane integrity in experimental models.

Electron Transport Chain Support

Research suggests that cardiolipin binding may help preserve cytochrome c in its role as an electron carrier while limiting its peroxidase activity, potentially supporting more efficient electron transport in mitochondria.

Oxidative Stress Reduction

Experimental studies indicate that SS-31 may reduce reactive oxygen species leakage by stabilizing mitochondrial membranes and limiting oxidative reactions associated with electron transport chain dysfunction.

Blood–Brain Barrier Permeability

SS-31 carries a net cationic charge at physiological pH, a property studied for its potential to facilitate membrane permeability and central nervous system exposure in laboratory models.

All mechanisms described are experimental observations and do not imply therapeutic or clinical benefit.

Structural and Chemical Characteristics

SS-31 is notable for its small size and unique charge distribution, which contribute to its mitochondrial targeting properties.

• Product Name: SS-31 50mg

• Form: Lyophilized powder

• Purity: Greater than 99%

• Peptide Type: Synthetic tetrapeptide

• Sequence: D-Arg–dimethylTyr–Lys–Phe–NH₂

• Molecular Formula: C32H49N9O5

• Molecular Weight: 639.8 g/mol

• Alternate Names: MTP-131, Elamipretide

Research Applications

SS-31 50mg may be utilized by qualified researchers in laboratory investigations involving:

• Mitochondrial structure and function studies

• Oxidative stress and reactive oxygen species research

• Cellular energy metabolism and ATP production models

• Neurodegeneration and central nervous system research models

All use must remain within controlled laboratory environments.

Regulatory Status and Use Disclaimer

• For research use only

• Not approved by the Food and Drug Administration

• Not intended for human or veterinary use

• Not intended to diagnose, treat, cure, or prevent any disease

• No established clinical safety, dosing, or efficacy data