MOTS-c 20mg Research Peptide

MOTS-c 20mg is a synthetic mitochondria-derived peptide (MDP) composed of 16 amino acids, encoded by the mitochondrial open reading frame of the 12S ribosomal ribonucleic acid. MOTS-c is expressed in tissues and plasma and has been studied as both a cell-specific signaling compound and a circulating mitokine involved in metabolic regulation, cellular stress responses, and adaptive signaling pathways. Supplied as a lyophilized powder with a reported purity greater than 99%, MOTS-c 20mg is intended exclusively for laboratory research use.

What Is MOTS-c 20mg?

MOTS-c 20mg is one of the few peptides encoded by mitochondrial DNA rather than nuclear DNA. Alongside Humanin, MOTS-c is among the most extensively studied mitochondrial-derived peptides. In experimental models, MOTS-c has been investigated for its role in energy metabolism, cellular adaptation to metabolic stress, and systemic signaling associated with mitochondrial function.

MOTS-c 20mg is an experimental research compound and is not approved for human or animal use.

Research Background

Research suggests that MOTS-c may act as a metabolic signaling molecule under conditions of cellular or metabolic stress. Experimental findings indicate that MOTS-c can translocate from the mitochondria to the nucleus, where it may influence gene expression pathways associated with antioxidant defense and metabolic regulation.

Studies also report that endogenous MOTS-c expression appears to decline with age, prompting investigation into its potential role in aging-related metabolic changes. Physical activity has been associated with increased endogenous MOTS-c levels in experimental models, linking it to exercise-related metabolic signaling pathways. All findings remain preclinical and have not been validated in human clinical trials.

Mechanisms of Research Interest

AMP-Activated Protein Kinase Pathway

MOTS-c 20mg has been studied for its potential to activate AMP-activated protein kinase, a central regulator of cellular energy balance involved in glucose uptake and lipid utilization research models.

Gene Regulation and Nuclear Signaling

Experimental data suggests MOTS-c may interact with genes containing antioxidant response elements, potentially influencing transcription factors such as nuclear factor erythroid-derived 2-like 2 in laboratory settings.

Metabolic Balance Research

MOTS-c has been investigated for its influence on the folate–methionine cycle and purine biosynthesis, pathways involved in shifting cellular priorities between anabolic and catabolic processes.

Systemic Metabolic Research

Animal studies have examined MOTS-c for its involvement in insulin sensitivity markers, glucose metabolism pathways, skeletal muscle performance signaling, and resistance to diet-induced metabolic stress.

All mechanisms described are experimental observations or theoretical models and do not imply clinical or therapeutic benefit.

Molecular and Chemical Information

• Product Name: MOTS-c 20mg

• Form: Lyophilized powder

• Purity: Greater than 99%

• Peptide Length: 16 amino acids

• Classification: Mitochondria-derived peptide

• Molecular Formula: C101H152N28O22S2

• Molecular Weight: 2174.64 g/mol

• Alternate Names: Mitochondrial-derived peptide MOTS-c, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid

Research Applications

MOTS-c 20mg may be utilized by qualified researchers in laboratory investigations involving:

• Mitochondrial signaling and metabolism research

• Cellular stress response and energy balance studies

• AMP-activated protein kinase pathway analysis

• Aging-related metabolic and exercise signaling models

All use must remain within controlled laboratory environments.

Regulatory Status and Use Disclaimer

• For research use only

• Not approved by the Food and Drug Administration

• Not intended for human or veterinary use

• Not intended to diagnose, treat, cure, or prevent any disease

• No established clinical safety, dosing, or efficacy data