MOTS-c 10mg Research Peptide

MOTS-c 10mg is a synthetic mitochondria-derived peptide (MDP) composed of 16 amino acids, corresponding to the mitochondrial open reading frame of the 12S ribosomal ribonucleic acid. MOTS-c is expressed in tissues and plasma and has been studied as both a cell-specific signaling molecule and a circulating mitokine involved in metabolic regulation and cellular stress responses. Supplied as a lyophilized powder with a reported purity greater than 99%, MOTS-c 10mg is intended exclusively for laboratory research use.

What Is MOTS-c 10mg?

MOTS-c 10mg is one of a small number of peptides encoded by mitochondrial DNA rather than nuclear DNA. Along with Humanin, MOTS-c is among the most extensively studied mitochondrial-derived peptides. In experimental models, MOTS-c has been investigated for its role in metabolic adaptation, energy balance signaling, and cellular responses to metabolic stress.

MOTS-c 10mg is an experimental research compound and is not approved for human or animal use.

Research Background

Research indicates that MOTS-c may act as a metabolic signaling molecule under conditions of cellular stress. Experimental findings suggest that MOTS-c can translocate from the mitochondria to the nucleus, where it may influence gene expression associated with antioxidant defenses and metabolic regulation.

Studies have also observed that endogenous MOTS-c levels appear to decline with age, prompting investigation into its role in aging-related metabolic changes. Physical activity has been reported to increase endogenous MOTS-c expression in experimental models, linking it to exercise-associated metabolic signaling pathways. All findings remain preclinical and have not been validated in human clinical trials.

Mechanisms of Research Interest

AMP-Activated Protein Kinase Activation

MOTS-c 10mg has been studied for its potential to activate AMP-activated protein kinase, a central regulator of cellular energy balance involved in glucose uptake and lipid utilization research.

Gene Regulation and Nuclear Signaling

Experimental data suggests MOTS-c may interact with genes containing antioxidant response elements, influencing transcription factors such as nuclear factor erythroid-derived 2-like 2 in laboratory models.

Metabolic Balance Pathway Research

MOTS-c has been investigated for its influence on the folate–methionine cycle and purine biosynthesis, pathways associated with shifting cellular priorities between anabolic and catabolic processes.

Systemic Metabolic Research

Animal studies have examined MOTS-c for its potential involvement in insulin sensitivity markers, glucose metabolism pathways, skeletal muscle performance signaling, and protection against diet-induced metabolic stress.

All mechanisms described are experimental observations or theoretical models and do not imply clinical or therapeutic benefit.

Molecular and Chemical Information

• Product Name: MOTS-c 10mg

• Form: Lyophilized powder

• Purity: Greater than 99%

• Peptide Length: 16 amino acids

• Classification: Mitochondria-derived peptide

• Molecular Formula: C101H152N28O22S2

• Molecular Weight: 2174.64 g/mol

• Alternate Names: Mitochondrial-derived peptide MOTS-c, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid

Research Applications

MOTS-c 10mg may be utilized by qualified researchers in laboratory investigations involving:

• Mitochondrial signaling and metabolism research

• Energy balance and cellular stress response studies

• AMP-activated protein kinase pathway analysis

• Aging-related metabolic and exercise signaling models

All use must remain within controlled laboratory environments.

Regulatory Status and Use Disclaimer

• For research use only

• Not approved by the Food and Drug Administration

• Not intended for human or veterinary use

• Not intended to diagnose, treat, cure, or prevent any disease

• No established clinical safety, dosing, or efficacy data